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RC E-Club KölnUniv.-Prof. Dr. Thomas BenzingDas Meeting wird online übertragen.RC E-Club Köln
Montag 2. Dezember 2024
21:00 Uhr

Univ.-Prof. Dr. Thomas Benzing
CRISPR - genome editing

MagicMonday


Thomas Benzing is Professor of Medicine and Chairman of the Department II of Internal Medicine at the University of Cologne. Benzing received his MD and clinical training at the University of Freiburg, Germany.

"CISPR gene editing" (pronounced /krɪspər/ "crisper") standing for "Clustered Regularly Interspaced Short Palindromic Repeats" is a genetic engineering technique in molecular biology by which the genomes of living organisms may be modified. It is based on a simplified version of the bacterial CRISPR-Cas9 antiviral defense system. By delivering the Cas9 nuclease complexed with a synthetic guide RNA (gRNA) into a cell, the cell´s genome can be cut at a desired location, allowing existing genes to be removed and/or new ones added in vivo.


Dr.Benzing writes in his article "Genome Editing with CRISPR/Cas9: First Steps Towards a new Era in Medicine?":

"The emergence of genome editing technologies can be regarded as one of the most groundbreaking revolutions in the history of science. Modern genome editing allows the introduction of precise mutations into the genome of virtually all cells and organisms without leaving any additional trace. Undoubtedly, genome editing with CRISPR/Cas9, often casually referred to as “genetic scissors”, will revolutionize medical research and development. However, at the same time it creates a great need for ethical considerations as it might hold risks for both people and the environment that cannot yet be fully assessed. While genome editing is already well established in laboratory research, clinical applications based on genome editing are close. For the first time, targeted corrections of genetic defects in somatic cells, stem cells as well as in the germ line appear technically feasible. This generates possible future scenarios that urgently require broad ethical and social discussions."(Dtsch Med Wochenschr 2019; 144(04): 276-281)



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